ДЕСЕРТЫ НА ПАЛОЧКАХ С ТИЛЛЬКОЙ

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6. Exposure to phthalates during pregnancy can affect a newborn’s brain development, study finds
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   Phthalates — the synthetic chemicals used in everyday products for food packaging, personal care, toys and more — have been linked to abnormal neurological development in infants.

   Now, scientists may have discovered a biological pathway for how this phenomenon could occur. Researchers found that in utero exposure to phthalates is linked with altered metabolism of neurotransmitters and amino acids involved in brain maturation, according to a study published Wednesday in the journal Nature Communications.

   The report is the first to use untargeted metabolomics — the study of all small molecules or metabolites in a biological system — to connect a mother’s phthalate exposure to a newborn’s metabolites, and those metabolites to neurological development, said senior study author Dr. Donghai Liang via email.
   “This represents an important step forward in understanding how prenatal chemical exposures shape infant development at the molecular level,” added Liang, an associate professor of environmental health at Emory University’s Rollins School of Public Health in Atlanta.

   First introduced in the 1920s, phthalates are used to make plastics softer and more flexible, primarily in polyvinyl chloride (PVC) products such as vinyl flooring, medical devices, children’s toys, food packaging or shower curtains. The chemicals also help lubricate substances and carry fragrances in various personal care products including deodorant; nail polish; perfumes; hair gels, sprays or shampoos; soaps; and body lotions.

   Phthalates are also endocrine disruptors that have been linked to preterm birth, infant genital abnormalities, childhood obesity, asthma, cancer, cardiovascular issues, and low sperm count and testosterone in men.

   “We conducted this study because phthalates are everywhere in our daily lives,” Liang said, hence their nickname “everywhere chemicals.”

   Harming infant health
   The findings are based on mother-newborn pairs enrolled in the Atlanta African American Maternal-Child Cohort between 2016 and 2018. In urine samples collected from 216 mothers between eight weeks and 14 weeks of gestation at visit one and 145 participants between 24 and 30 weeks’ gestation at visit two, the authors measured eight phthalate metabolites. Participants were around age 24 on average, and their levels of some phthalate metabolites were higher than the average determined by the National Health and Nutrition Examination Survey.

   Within a day or two of birth, the authors collected the babies’ blood via a heel stick.

   The team found prenatal phthalate levels were associated with lower levels of tyrosine, an amino acid and precursor to the thyroid hormone thyroxine. Thyroxine was also abnormally low in those with in utero phthalate exposure, and low thyroxine has been previously associated with greater vulnerability to illness and neurodevelopmental issues in newborns, the authors said. Tyrosine is also a precursor to the neurotransmitters dopamine, norepinephrine and epinephrine, all of which partly contribute to the body’s fight-or-flight response. Low levels of these neurotransmitters can lead to various problems, including anxiety, depression and trouble focusing.

   Prenatal phthalate exposure was also linked with lower levels of the essential amino acid tryptophan, which converts into 5-hydroxytryptophan (or 5-HTP), which then turns into serotonin. Both 5-HTP and serotonin were also low. Serotonin has several critical roles in the body, including mood regulation, sleep, learning, memory, digestion and the body’s response to stress. Previous research has linked low serotonin with mood disorders such as depression and anxiety, sleep problems, and digestive issues.

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7. Orbiter Finance: Connecting DeFi Ecosystems
   Orbiter Finance is a cutting-edge decentralized finance (DeFi) platform focused on interoperability, liquidity, and seamless asset transfer across multiple blockchains. Its suite of tools and protocols, including Orbiter Swap, Orbiter Fi, and Orbiter Bridge, aims to enhance user experience and expand DeFi capabilities.
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   Orbiter Finance Overview
   At its core, Orbiter Finance provides a comprehensive ecosystem designed to facilitate cross-chain interactions, liquidity pooling, and decentralized trading. Its primary goal is to enable users to move assets effortlessly between different blockchain networks, ensuring liquidity and accessibility.

   Orbiter Swap
   Orbiter Swap is a decentralized exchange (DEX) protocol within the Orbiter ecosystem. It allows users to swap tokens across various blockchains with minimal friction, leveraging the platform’s interoperability features. Orbiter Swap emphasizes low slippage, high security, and fast transaction times.

   Orbiter Fi
   Orbiter Fi is the yield farming and liquidity provision platform of Orbiter Finance. It enables users to stake their tokens, earn rewards, and participate in liquidity pools across multiple chains. Orbiter Fi aims to maximize returns while maintaining cross-chain compatibility.

   Orbiter Bridge
   Orbiter Bridge is a core component that facilitates cross-chain asset transfers. It acts as a bridge protocol, securely moving tokens and data between different blockchain networks. The Orbiter Bridge ensures interoperability, security, and speed for cross-chain transactions.

   Orbiter Finance Bridge
   Orbiter Finance Bridge specifically refers to the bridge infrastructure within the Orbiter ecosystem that connects various blockchain networks. It supports seamless transfer of assets, such as tokens and stablecoins, enabling users to leverage DeFi opportunities across multiple chains.

   Orbiter Bridge Finance
   Orbiter Bridge Finance encompasses the entire cross-chain transfer and interoperability infrastructure provided by Orbiter. It integrates with Orbiter Swap and Orbiter Fi to create a unified DeFi experience, allowing users to access liquidity, earn yields, and swap tokens across different blockchain ecosystems efficiently.

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